Drug Info
Scream Cream is commonly prescribed for:
  • Libido enhancement
Multiple strength combinations of Scream Cream are available:
  • Aminophylline 30mg/ml
  • Ergoloid Mesylate 0.5mg/ml
  • L-Arginine 60mg/ml
  • Pentoxifylline 50mg/ml
  • Sildenafil Citrate 10mg/ml
  • Testosterone 1mg/ml
The dosage form available for Scream Cream is transdermal cream. Empower Pharmacy’s creams are compounded under the stringent USP 795 guidelines. Our quality-assurance process ensures the potency, consistency, uniformity, and beyond use dating (BUD) of every compound we dispense.

Scream Cream

Pharmacologic Classifications: Vasodilator

General Information
Scream Cream is a topical cream that, when applied to the clitoris or external genitalia, increases blood flow to the applied area and has been reported to improve sensitivity and rates of orgasm. Compounded from a mixture of prescription products, Scream Cream is designed to act locally without substantial absorption into the blood stream. This transdermal (absorbed through the skin) cream is comprised of six different medications and products which include:  aminophylline, ergoloid mesylate, L-arginine, pentoxifylline, sildenafil citrate, and testosterone.  This synergistic medication draws upon the properties of each ingredient (one bronchodilator, four  vasodilators, and the potent sex steroid hormone testosterone) to provide female libido (sex drive) and sexual stimulation enhancement. 

Mechanism of Action
Scream Cream’s four vasodilators contribute by relaxing the vascular smooth muscles, which consequently dilates peripheral blood vessels (arteries and especially veins).  Dilatation (widening) of the blood vessels promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload).  Such medications are primarily used to treat or prevent heart disease due to arterial plaque buildup, blood clots, platelet clumping, and to increase blood flow through the coronary artery.  These medications also help to ease migraines, improve blood pressure to organs and tissues, lessen recovery time after surgery, increase immune-boosting effects, and speed up tissue repair/wound healing.  However, they contribute to the Scream Cream complex by exerting effects on the female genitalia.  The same vasoactive mechanisms used by these agents to improve blood flow to the heart, lungs, and many other bodily tissues and functions, is believed to also increase vaginal blood flow during stimulation, thereby effectively aiding in the treatment of sexual dysfunctions.

In combination, these prescription-strength products comprise Scream Cream – a topical cream which, when applied to the clitoris or external genitalia, increases blood flow to the applied area and has been reported to improve both sexual sensitivity and orgasm frequency.  

Transdermal application results in primarily localized action. As such, the expected pharmacokinetics for each of Scream Cream’s six compounds mimics those of the individual compounds when administered topically. The differences resulting from simultaneous application have not been studied.

Scream Cream is typically indicated in the treatment of female anorgasmia or sexual dysfunction.

There is an alternative formulation available if you have a history of genital herpes. This medicine does not protect you against HIV infections or any other sexually transmitted diseases. This medication may darken over time.

If you have contraindications with intercourse, you should consult your healthcare provider before using the medication and engaging in intercourse. You should not use this cream if you are allergic to any of the ingredients, have a history of genital herpes (*L-Arginine may facilitate replication of the herpes virus. An alternative formulation without L-Arginine is available.), chronic vaginal infections, or serious medical conditions such as heart disease or autoimmune disorder.

Additionally, despite acting almost exclusively locally, the contraindications for each of Scream Cream’s compounds may apply. Provide your physician with information on Scream Cream, as well as a list of your medical conditions before asking for a prescription.

DO NOT USE SCREAM CREAM while pregnant or trying to become pregnant: one of Scream Cream’s ingredients, Testosterone, is an FDA pregnancy risk category X (adverse fetal effects are expected)[1].

As a testosterone-containing product, Scream Cream is contraindicated in women who are breast-feeding. [2][3]

Scream Cream acts synergistically via six distinct pharmacologically active compounds and each has its own list of compounds it interacts with. Interactions resulting from the combination of these compounds have not been studied and may include more than the sum of all compounds. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Adverse Reactions & Side Effects
Scream Cream promotes blood flow to the applied area to improve sensitivity and rates of orgasm: it does not produce an orgasm. If not completely absorbed, it may cause irritation with your partner.

Scream Cream is formulated to act locally so side effects are minimal, but may include skin irritation, headache, dizziness, and restlessness. However, possible side effects include but are not limited to those of each of Scream Cream’s components. The side effects of these compounds in combination have not been studied.

Call your health care provider immediately if you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness, red, swollen painful area on the leg

How is this medication best taken?
Apply 1/4 - 1/2 ml of cream onto clitoris and/or external genital 15-30 minutes prior to sex. Scream Cream should be massaged gently into the area until it is completely absorbed. Duration of effect is 30 minutes to 2 hours and reapplication may occur as needed.

Make sure to talk to your physician or pharmacist about how frequently you should be using Scream Cream and how much you should apply.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.

General Statements
Do not share or take any one else's medicine. Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins. This patient information summarizes the most important information about your medication; if you would like more information, talk with your doctor.

  • 1. Axiron (testosterone) topical solution, package insert. Indianapolis, IN: Lilly USA, LLC; 2011 Dec.
  • 2. Axiron (testosterone) topical solution, package insert. Indianapolis, IN: Lilly USA, LLC; 2011 Dec.
  • 3. Androderm (testosterone transdermal system) package insert. Corona, CA: Watson Pharma, Inc.; 2014 Jun.